Now, the 37-year-old actress is expecting her first child with husband Will Kopelman. The couple married on June 2 at Barrymore's Montecito, Calif. estate and are expecting their baby boy or girl any day now.
While Barrymore may have changed her mind on a baby name in the past 17 years, she told Jay Leno on The Tonight Show in February that she hopes to have multiple children with art consultant Kopelman, 35.
"We'll start with one," she said. "See how it goes and if we could be so blessed . . . that would be wonderful."