4) The "Tootsie" Ending: In a decision to up the ratings, the network decides most wisely to have a live taping of Grey's on national TV. It is then that Katherine Heigl takes off her wig and reveals she's really a man.* All this drama was her inner identity crisis! She stars in a remake of "Rain Man," wins a few Oscars, and it turns out that Kevin Heigl is a really rad dude.
*NOTE TO HEIGL'S REPS: This doesn't even have to be true, it might just be a great PR angle to make her more relatable and likable. Worked for Chaz Bono.