After TMZ reported that plastic surgeon Nassif plans to file for legal separation this week, hotel mogul Maloof told Radar Online, "I'm so sorry that this is happening, but my children are my life, and sometimes we need to do what's best for them."
On the first two seasons of Bravo's smash reality show, Maloof and Nassif bickered -- seemingly good-naturedly -- on camera.
Their young sons -- Gavin and twins Colin and Christian -- were rarely seen on camera for the show, co-starring Kim and Kyle Richards, Lisa Vanderpump, Camille Grammer, Taylor Armstrong and Brandi Glanville.
"It's an unfortunate situation, but I have to have my kids' best interest at heart," Maloof added.
It's not the first marriage to disintegrate on "RHOBH." The end of both Grammer and Armstrong's marriages also played out during the show. Tragically, Russell Armstrong took his own life in August 2011.
Keep clicking to see photos of the couple during happier times ...