1) The Soap Opera Ending: Five weeks without Izzie puts Seattle Grace in a slump. They beg her to come back, but lo and behold, a girl resembling Izzie comes in her place! Turns out the woman who claimed to be Izzie all these years was in fact Lizzie, Izzie Stevens' evil twin sister. Izzie tracked Lizzie down after being locked in a dungeon for four years and sought her revenge. Real Izzie shall be played by Sarah Chalke.